Structure of PDB 1zxb Chain A

Receptor sequence
>1zxbA (length=289) Species: 5833 (Plasmodium falciparum) [Search protein sequence]
EDICFIAGIGDTNGYGWGIAKELSKRNVKIIFGIWPPVYNIFMKNYKNGK
FDNDMIIDKDKKMNILDMLPFDASFDTANDIDEETKNNKRYNMLQNYTIE
DVANLIHQKYGKINMLVHSLANAKEVQKDLLNTSRKGYLDALSKSSYSLI
SLCKYFVNIMKPQSSIISLTYHASQKVVPGYGGGMSSAKAALESDTRVLA
YHLGRNYNIRINTISAGPLKSRAATAINKYTFIDYAIEYSEKYAPLRQKL
LSTDIGSVASFLLSRESRAITGQTIYVDNGLNIMFLPDD
3D structure
PDB1zxb Synthesis, biological activity, and X-ray crystal structural analysis of diaryl ether inhibitors of malarial enoyl acyl carrier protein reductase. Part 1: 4'-Substituted triclosan derivatives.
ChainA
Resolution2.68 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) Y277 K285
Catalytic site (residue number reindexed from 1) Y181 K189
Enzyme Commision number 1.3.1.9: enoyl-[acyl-carrier-protein] reductase (NADH).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NAD A I105 G110 Y111 W131 F167 D168 A169 S215 L216 A217 L265 Y267 K285 P314 L315 S317 A319 I9 G14 Y15 W35 F71 D72 A73 S119 L120 A121 L169 Y171 K189 P218 L219 S221 A223
BS02 TN3 A A217 V222 Y267 Y277 A319 A320 I323 A121 V126 Y171 Y181 A223 A224 I227
Gene Ontology
Molecular Function
GO:0004318 enoyl-[acyl-carrier-protein] reductase (NADH) activity
Biological Process
GO:0006633 fatty acid biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:1zxb, PDBe:1zxb, PDBj:1zxb
PDBsum1zxb
PubMed16198563
UniProtQ9BH77

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