Structure of PDB 1zx9 Chain A

Receptor sequence
>1zx9A (length=453) Species: 287 (Pseudomonas aeruginosa) [Search protein sequence]
PVQVAVIGSGGAAMAAALKAVEQGAQVTLIERGTIGGTCVNVGCVPSKIM
IRAAHIAHLRRESPFDGGIAATVPTIDRSKLLAQQQARVDELRHAKYEGI
LGGNPAITVVHGEARFKDDQSLTVRLNEGGERVVMFDRCLVATGASPAVP
PIPGLKESPYWTSTEALASDTIPERLAVIGSSVVALELAQAFARLGSKVT
VLARNTLFFREDPAIGEAVTAAFRAEGIEVLEHTQASQVAHMDGEFVLTT
THGELRADKLLVATGRTPNTRSLALDAAGVTVNAQGAIVIDQGMRTSNPN
IYAAGDCTDQPQFVYVAAAAGTRAAINMTGGDAALDLTAMPAVVFTDPQV
ATVGYSEAEAHHDGIETDSRTLTLDNVPRALANFDTRGFIKLVIEEGSHR
LIGVQAVAPEAGELIQTAALAIRNRMTVQELADQLFPYLTMVEGLKLAAQ
TFN
3D structure
PDB1zx9 NmerA, the Metal Binding Domain of Mercuric Ion Reductase, Removes Hg(2+) from Proteins, Delivers It to the Catalytic Core, and Protects Cells under Glutathione-Depleted Conditions
ChainA
Resolution1.9 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) G14 I38 C42 C47 S50 V76 P77 V186 E190 A321 F439 Y441 E446
Catalytic site (residue number reindexed from 1) G11 I35 C39 C44 S47 V73 P74 V183 E187 A318 F436 Y438 E443
Enzyme Commision number 1.16.1.1: mercury(II) reductase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FAD A I10 G11 G13 A15 E34 R35 G40 T41 C42 G46 C47 K51 E116 A117 T146 G147 R269 G308 D309 Q315 F316 V317 Y318 F348 I7 G8 G10 A12 E31 R32 G37 T38 C39 G43 C44 K48 E113 A114 T143 G144 R266 G305 D306 Q312 F313 V314 Y315 F345
Gene Ontology
Molecular Function
GO:0016152 mercury (II) reductase (NADP+) activity
GO:0016491 oxidoreductase activity
GO:0016668 oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor
GO:0045340 mercury ion binding
GO:0050660 flavin adenine dinucleotide binding
GO:0050661 NADP binding
Biological Process
GO:0050787 detoxification of mercury ion

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Molecular Function
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Biological Process
External links
PDB RCSB:1zx9, PDBe:1zx9, PDBj:1zx9
PDBsum1zx9
PubMed16114877
UniProtP00392|MERA_PSEAI Mercuric reductase (Gene Name=merA)

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