Structure of PDB 1zvl Chain A

Receptor sequence
>1zvlA (length=420) Species: 10116 (Rattus norvegicus) [Search protein sequence]
GPRFLKVKNWETDVVLTDTLHLKSTLETGCTEHICMGSIMLPSQHTRKPE
DVRTKDQLFPLAKEFLDQYYSSIKRFGSKAHMDRLEEVNKEIESTSTYQL
KDTELIYGAKHAWRNASRCVGRIQWSKLQVFDARDCTTAHGMFNYICNHV
KYATNKGNLRSAITIFPQRTDGKHDFRVWNSQLIRYAGYKQPDGSTLGDP
ANVQFTEICIQQGWKAPRGRFDVLPLLLQANGNDPELFQIPPELVLEVPI
RHPKFDWFKDLGLKWYGLPAVSNMLLEIGGLEFSACPFSGWYMGTEIGVR
DYCDNSRYNILEEVAKKMDLDMRKTSSLWKDQALVEINIAVLYSFQSDKV
TIVDHHSATESFIKHMENEYRCRGGCPADWVWIVPPMSGSITPVFHQEML
NYRLTPSFEYQPDPWNTHVW
3D structure
PDB1zvl Structural Analysis of Isoform-Specific Inhibitors Targeting the Tetrahydrobiopterin Binding Site of Human Nitric Oxide Synthases.
ChainA
Resolution2.5 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) C415 R418 W587 E592
Catalytic site (residue number reindexed from 1) C119 R122 W291 E296
Enzyme Commision number 1.14.13.39: nitric-oxide synthase (NADPH).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A C326 C331 C30 C35
BS02 HEM A W409 C415 V416 Q420 F584 S585 W587 E592 W678 F704 Y706 W113 C119 V120 Q124 F288 S289 W291 E296 W382 F408 Y410
BS03 H4B A S334 R596 V677 W678 S38 R300 V381 W382
BS04 ARG A Q478 V567 Y588 E592 D597 Q182 V271 Y292 E296 D301
BS05 H4B A F691 H692 Q693 F395 H396 Q397
Gene Ontology
Molecular Function
GO:0004517 nitric-oxide synthase activity
GO:0020037 heme binding
Biological Process
GO:0006809 nitric oxide biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:1zvl, PDBe:1zvl, PDBj:1zvl
PDBsum1zvl
PubMed16033258
UniProtP29476|NOS1_RAT Nitric oxide synthase 1 (Gene Name=Nos1)

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