Structure of PDB 1zuc Chain A

Receptor sequence
>1zucA (length=251) Species: 9606 (Homo sapiens) [Search protein sequence]
QLIPPLINLLMSIEPDVIYAGHDNTKPDTSSSLLTSLNQLGERQLLSVVK
WSKSLPGFRNLHIDDQITLIQYSWMSLMVFGLGWRSYKHVSGQMLYFAPD
LILNEQRMKESSFYSLCLTMWQIPQEFVKLQVSQEEFLCMKVLLLLNTIP
LEGLRSQTQFEEMRSSYIRELIKAIGLRQKGVVSSSQRFYQLTKLLDNLH
DLVKQLHLYCLNTFIQSRALSVEFPEMMSEVIAAQLPKILAGMVKPLLFH
K
3D structure
PDB1zuc Molecular and pharmacological properties of a potent and selective novel nonsteroidal progesterone receptor agonist tanaproget
ChainA
Resolution2.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 T98 A L718 N719 Q725 M759 F778 L797 T894 L37 N38 Q44 M78 F97 L116 T213 MOAD: ic50=1.7nM
PDBbind-CN: -logKd/Ki=8.77,IC50=1.7nM
BindingDB: IC50=0.5nM,EC50=0.15nM
External links
PDB RCSB:1zuc, PDBe:1zuc, PDBj:1zuc
PDBsum1zuc
PubMed15937332
UniProtP06401|PRGR_HUMAN Progesterone receptor (Gene Name=PGR)

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