Structure of PDB 1zsq Chain A

Receptor sequence
>1zsqA (length=513) Species: 9606 (Homo sapiens) [Search protein sequence]
MEEPPLLPGENIKDMAKDVTYICPFTGAVRGTLTVTNYRLYFKSMERDPP
FVLDASLGVINRVEKIGGASSRGENSYGLETVCKDIRNLRFAHKPEGRTR
RSIFENLMKYAFPVSNNLPLFAFEYKEVFPENGWKLYDPLLEYRRQGIPN
ESWRITKINERYELCDTYPALLVVPANIPDEELKRVASFRSRGRIPVLSW
IHPESQATITRCSQPMVGVSGKRSKEDEKYLQAIMDSNAQSHKIFIFDAR
PSVNAVANKAKGGGYESEDAYQNAELVFLDIHNIHVMRESLRKLKEIVYP
NIEETHWLSNLESTHWLEHIKLILAGALRIADKVESGKTSVVVHSSDGWD
RTAQLTSLAMLMLDGYYRTIRGFEVLVEKEWLSFGHRFQLRVGHGDKNHA
DADRSPVFLQFIDCVWQMTRQFPTAFEFNEYFLITILDHLYSCLFGTFLC
NSEQQRGKENLPKRTVSLWSYINSQLEDFTNPLYGSYSNHVLYPVASMRH
LELWVGYYIRWNP
3D structure
PDB1zsq Molecular basis for substrate recognition by MTMR2, a myotubularin family phosphoinositide phosphatase
ChainA
Resolution1.82 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.3.64: phosphatidylinositol-3-phosphatase.
3.1.3.95: phosphatidylinositol-3,5-bisphosphate 3-phosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 PIB A N330 K333 N355 I356 S417 S418 D419 W421 D422 R423 R463 N258 K261 N283 I284 S345 S346 D347 W349 D350 R351 R391
External links
PDB RCSB:1zsq, PDBe:1zsq, PDBj:1zsq
PDBsum1zsq
PubMed16410353
UniProtQ13614|MTMR2_HUMAN Myotubularin-related protein 2 (Gene Name=MTMR2)

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