Structure of PDB 1zsh Chain A

Receptor sequence
>1zshA (length=354) Species: 9913 (Bos taurus) [Search protein sequence]
TRVFKKASPNGKLTVYLGKRDFVDHIDLVEPVDGVVLVDPEYLKERRVYV
TLTCAFRYGREDLDVLGLTFRKDLFVANVQSFPPAPEDKKPLTRLQERLI
KKLGEHAYPFTFEIPPNLPCSVTLQPGPEDTGKACGVDYEVKAFCAENLE
EKIHKRNSVRLVIRKVQYAPERPGPQPTAETTRQFLMSDKPLHLEASLDK
EIYYHGEPISVNVHVTNNTNKTVKKIKISVRQYADICLFNTAQYKCPVAM
EEADDTVAPSSTFCKVYTLTPFLANNREKRGLALDGKLKHEDTNLASSTL
LREGANREILGIIVSYKVKVKLVVSSSDVAVELPFTLMHPKDIVFEDFAR
QRLK
3D structure
PDB1zsh Nonvisual arrestin oligomerization and cellular localization are regulated by inositol hexakisphosphate binding
ChainA
Resolution2.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG A P175 E176 P170 E171
BS02 IHP A R236 K250 K324 K326 R231 K245 K319 K321 PDBbind-CN: -logKd/Ki=7.07,Kd=85nM
Gene Ontology
Molecular Function
GO:0000822 inositol hexakisphosphate binding
GO:0001664 G protein-coupled receptor binding
GO:0005515 protein binding
GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding
GO:0030276 clathrin binding
GO:0032050 clathrin heavy chain binding
GO:0033130 acetylcholine receptor binding
GO:0035612 AP-2 adaptor complex binding
GO:0036094 small molecule binding
GO:0060090 molecular adaptor activity
Biological Process
GO:0001934 positive regulation of protein phosphorylation
GO:0002029 desensitization of G protein-coupled receptor signaling pathway
GO:0002031 G protein-coupled receptor internalization
GO:0002092 positive regulation of receptor internalization
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0007165 signal transduction
GO:0007601 visual perception
GO:0009968 negative regulation of signal transduction
GO:0015031 protein transport
GO:0031623 receptor internalization
GO:0045746 negative regulation of Notch signaling pathway
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0072583 clathrin-dependent endocytosis
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005905 clathrin-coated pit
GO:0030132 clathrin coat of coated pit
GO:0031143 pseudopodium
GO:0031410 cytoplasmic vesicle
GO:0042995 cell projection

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1zsh, PDBe:1zsh, PDBj:1zsh
PDBsum1zsh
PubMed16439357
UniProtP17870|ARRB1_BOVIN Beta-arrestin-1 (Gene Name=ARRB1)

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