Structure of PDB 1zpz Chain A

Receptor sequence
>1zpzA (length=233) Species: 9606 (Homo sapiens) [Search protein sequence]
IVGGTASVRGEWPWQVTLHTTSPTQRHLCGGSIIGNQWILTAAHCFYGVE
SPKILRVYSGILNQSEIAEDTSFFGVQEIIIHDQYKMAESGYDIALLKLE
TTVNYTDSQRPISLPSKGDRTDCWVTGWGYRKLRDKIQNTLQKAKIPLVT
NEECQKRYRGHKITHKMICAGYREGGKDACKGDSGGPLSCKHNEVWHLVG
ITSWGEGCAQRERPGVYTNVVEYVDWILEKTQA
3D structure
PDB1zpz Design, Synthesis and Biological Evaluation of Peptidomimetic FXIa Inhibitors
ChainA
Resolution2.5 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H57 D102 K192 G193 D194 S195 G196
Catalytic site (residue number reindexed from 1) H44 D93 K181 G182 D183 S184 G185
Enzyme Commision number 3.4.21.27: coagulation factor XIa.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 BUK A H57 E98 D189 A190 C191 K192 G193 D194 S195 S214 W215 G216 H44 E89 D178 A179 C180 K181 G182 D183 S184 S203 W204 G205
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:1zpz, PDBe:1zpz, PDBj:1zpz
PDBsum1zpz
PubMed
UniProtP03951|FA11_HUMAN Coagulation factor XI (Gene Name=F11)

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