Structure of PDB 1znx Chain A

Receptor sequence
>1znxA (length=182) Species: 1773 (Mycobacterium tuberculosis) [Search protein sequence]
VGRVVVLSGPSAVGKSTVVRCLRERIPNLHFSVSATTRAPRPGEVDGVDY
HFIDPTRFQQLIDQGELLEWAEIHGGLHRSGTLAQPVRAAAATGVPVLIE
VDLAGARAIKKTMPEAVTVFLAPPSWQDLQARLIGRGTETADVIQRRLDT
ARIELAAQGDFDKVVVNRRLESACAELVSLLV
3D structure
PDB1znx Unique GMP-binding site in Mycobacterium tuberculosis guanosine monophosphate kinase
ChainA
Resolution2.35 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.4.8: guanylate kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 5GP A S53 R57 R60 Y69 E88 I92 S99 G100 S34 R38 R41 Y50 E69 I73 S80 G81
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0004017 adenylate kinase activity
GO:0004385 guanylate kinase activity
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0019002 GMP binding
GO:0019003 GDP binding
Biological Process
GO:0006163 purine nucleotide metabolic process
GO:0016310 phosphorylation
GO:0046037 GMP metabolic process
GO:0046710 GDP metabolic process
GO:0046940 nucleoside monophosphate phosphorylation
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1znx, PDBe:1znx, PDBj:1znx
PDBsum1znx
PubMed16288457
UniProtP9WKE9|KGUA_MYCTU Guanylate kinase (Gene Name=gmk)

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