Structure of PDB 1zm8 Chain A

Receptor sequence
>1zm8A (length=239) Species: 1167 (Anabaena sp.) [Search protein sequence]
ISVHLLLGNPSGATPTKLTPDNYLMVKNQYALSYNNSKGTANWVAWQLNS
SWLGNAERQDNFRPDKTLPAGWVRVTPSMYSGSGYARGHIAPSADRTKTT
EDNAATFLMTNMMPQTPDNNRNTWGNLEDYCRELVSQGKELYIVAGPNGS
LGKPLKGKVTVPKSTWKIVVVLDSPGSGLEGITANTRVIAVNIPNDPELN
NDWRAYKVSVDELESLTGYDFLSNVSPNIQTSIESKVDN
3D structure
PDB1zm8 Structural Insights into the Mechanism of Nuclease A, a beta beta alpha Metal Nuclease from Anabaena.
ChainA
Resolution1.9 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H124 N146 N155 E163
Catalytic site (residue number reindexed from 1) H89 N111 N120 E128
Enzyme Commision number 3.1.30.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MN A D246 E249 E269 D211 E214 E234
BS02 MN A E249 D255 F256 Q265 E269 E214 D220 F221 Q230 E234
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0016787 hydrolase activity
GO:0046872 metal ion binding

View graph for
Molecular Function
External links
PDB RCSB:1zm8, PDBe:1zm8, PDBj:1zm8
PDBsum1zm8
PubMed15897201
UniProtP38446|NUCA_NOSS1 Nuclease (Gene Name=nucA)

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