Structure of PDB 1zli Chain A

Receptor sequence
>1zliA (length=306) Species: 9606 (Homo sapiens) [Search protein sequence]
TGHSYEKYNNWETIEAWTQQVATENPALISRSVIGTTFEGRAIYLLKVGK
AGQNKPAIFMDCGFHAREWISPAFCQWFVREAVRTYGREIQVTELLNKLD
FYVLPVLNIDGYIYTWTKSRFWRKTRSTHTGSSCIGTDPNRNFDAGWCEI
GASRNPCDETYCGPAAESEKETKALADFIRNKLSSIKAYLTIHSYSQMMI
YPYSYAYKLGENNAELNALAKATVKELASLHGTKYTYGPGATTIYPAAGG
SDDWAYDQGIRYSFTFELRDTGRYGFLLPESQIRATCEETFLAIKYVASY
VLEHLY
3D structure
PDB1zli The Three-Dimensional Structures of Tick Carboxypeptidase Inhibitor in Complex with A/B Carboxypeptidases Reveal a Novel Double-headed Binding Mode
ChainA
Resolution2.09 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H69 E72 R127 H196 E270
Catalytic site (residue number reindexed from 1) H65 E68 R123 H193 E267
Enzyme Commision number 3.4.17.2: carboxypeptidase B.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A H69 E72 H196 H65 E68 H193
Gene Ontology
Molecular Function
GO:0004181 metallocarboxypeptidase activity
GO:0008270 zinc ion binding
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:1zli, PDBe:1zli, PDBj:1zli
PDBsum1zli
PubMed15961103
UniProtP15086|CBPB1_HUMAN Carboxypeptidase B (Gene Name=CPB1)

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