Structure of PDB 1zl7 Chain A

Receptor sequence
>1zl7A (length=122) Species: 8726 (Bothrops jararacussu) [Search protein sequence]
SLWQFGKMINYVMGESGVLQYLSYGCYCGLGGQGQPTDATDRCCFVHDCC
YGKVTGCNPKIDSYTYSKKNGDVVCGGDNPCKKQICECDRVATTCFRDNK
DTYDIKYWFYGAKNCQEKSEPC
3D structure
PDB1zl7 Insights into metal ion binding in phospholipases A(2): ultra high-resolution crystal structures of an acidic phospholipase A(2) in the Ca(2+) free and bound states.
ChainA
Resolution1.6 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) Y27 G29 G31 H47 D48 Y51 Y64 D89
Catalytic site (residue number reindexed from 1) Y27 G29 G31 H47 D48 Y51 Y64 D89
Enzyme Commision number 3.1.1.4: phospholipase A2.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA A Y27 L30 G31 G32 D48 Y27 L30 G31 G32 D48
Gene Ontology
Molecular Function
GO:0004623 phospholipase A2 activity
GO:0005509 calcium ion binding
GO:0005543 phospholipid binding
GO:0016787 hydrolase activity
GO:0046872 metal ion binding
GO:0047498 calcium-dependent phospholipase A2 activity
GO:0090729 toxin activity
Biological Process
GO:0006644 phospholipid metabolic process
GO:0008217 regulation of blood pressure
GO:0016042 lipid catabolic process
GO:0035821 modulation of process of another organism
GO:0042742 defense response to bacterium
GO:0050482 arachidonate secretion
Cellular Component
GO:0005576 extracellular region

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Cellular Component
External links
PDB RCSB:1zl7, PDBe:1zl7, PDBj:1zl7
PDBsum1zl7
PubMed16376474
UniProtQ8AXY1|PA2A_BOTJR Acidic phospholipase A2 BthA-1

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