Structure of PDB 1zkq Chain A

Receptor sequence
>1zkqA (length=482) Species: 10090 (Mus musculus) [Search protein sequence]
QQSFDLLVIGGGSGGLACAKEAAQLGKKVAVADYVEPSPRGTKWGLGGTC
VNVGCIPKKLMHQAALLGGMIRDAHHYGWEVAQPVQHNWKTMAEAVQNHV
KSLNWGHRVQLQDRKVKYFNIKASFVDEHTVRGVDKGGKATLLSAEHIVI
ATGGRPRYPTQVKGALEYGITSDDIFWLKESPGKTLVVGASYVALECAGF
LTGIGLDTTVMMRSIPLRGFDQQMSSLVTEHMESHGTQFLKGCVPSHIKK
LPTNQLQVTWEDHASGKEDTGTFDTVLWAIGRVPETRTLNLEKAGISTNP
KNQKIIVDAQEATSVPHIYAIGDVAEGRPELTPTAIKAGKLLAQRLFGKS
STLMDYSNVPTTVFTPLEYGCVGLSEEEAVALHGQEHVEVYHAYYKPLEF
TVADRDASQCYIKMVCMREPPQLVLGLHFLGPNAGEVTQGFALGIKCGAS
YAQVMQTVGIHPTCSEEVVKLHISKRSGLEPT
3D structure
PDB1zkq Crystal structures of oxidized and reduced mitochondrial thioredoxin reductase provide molecular details of the reaction mechanism.
ChainA
Resolution2.6 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) L82 C86 C91 K94 Y228 E232 G495 H497 E502
Catalytic site (residue number reindexed from 1) L46 C50 C55 K58 Y192 E196 G459 H461 E466
Enzyme Commision number 1.8.1.9: thioredoxin-disulfide reductase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FAD A S49 G50 D69 Y70 G84 T85 C86 G90 C91 K94 K158 A159 T188 G189 Y228 V229 R318 G358 D359 E366 L367 T368 S13 G14 D33 Y34 G48 T49 C50 G54 C55 K58 K122 A123 T152 G153 Y192 V193 R282 G322 D323 E330 L331 T332
Gene Ontology
Molecular Function
GO:0004791 thioredoxin-disulfide reductase (NADPH) activity
GO:0005515 protein binding
GO:0016491 oxidoreductase activity
GO:0016668 oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor
GO:0042803 protein homodimerization activity
GO:0050660 flavin adenine dinucleotide binding
Biological Process
GO:0000305 response to oxygen radical
GO:0006979 response to oxidative stress
GO:0007507 heart development
GO:0030097 hemopoiesis
GO:0045454 cell redox homeostasis
GO:0098869 cellular oxidant detoxification
Cellular Component
GO:0005739 mitochondrion

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1zkq, PDBe:1zkq, PDBj:1zkq
PDBsum1zkq
PubMed16217027
UniProtQ9JLT4|TRXR2_MOUSE Thioredoxin reductase 2, mitochondrial (Gene Name=Txnrd2)

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