Structure of PDB 1ziv Chain A

Receptor sequence
>1zivA (length=308) Species: 9606 (Homo sapiens) [Search protein sequence]
SFEQMRQECLQRGTLFEDADFPASNSSLFYSPQIPFVWKRPGEIVKNPEF
ILGGATRTDICQGELGDCWLLAAIASLTLNQKALARVIPQDQSFGPGYAG
IFHFQFWQHSEWLDVVIDDRLPTFRDRLVFLHSADHNEFWSALLEKAYAK
LNGSYEALKGGSAIEAMEDFTGGVAETFQTKEAPENFYEILEKALKRGSL
LGCFIDTRSAAESEARTPFGLIKGHAYSVTGIDQVSFRGQRIELIRIRNP
WGQVEWNGSWSDSSPEWRSVGPAEQKRLCHTALDDGEFWMAFKDFKAHFD
KVEICNLT
3D structure
PDB1ziv The crystal structures of human calpains 1 and 9 imply diverse mechanisms of action and auto-inhibition.
ChainA
Resolution2.31 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) Q91 C97 H254 N278 W280
Catalytic site (residue number reindexed from 1) Q62 C68 H225 N249 W251
Enzyme Commision number 3.4.22.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA A E284 D291 L312 D314 E316 E255 D262 L283 D285 E287
BS02 CA A L81 G83 D88 E167 L52 G54 D59 E138
Gene Ontology
Molecular Function
GO:0004198 calcium-dependent cysteine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:1ziv, PDBe:1ziv, PDBj:1ziv
PDBsum1ziv
PubMed17157313
UniProtO14815|CAN9_HUMAN Calpain-9 (Gene Name=CAPN9)

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