Structure of PDB 1zhp Chain A

Receptor sequence
>1zhpA (length=237) Species: 9606 (Homo sapiens) [Search protein sequence]
IVGGTASVRGEWPWQVTLHTTSPTQRHLCGGSIIGNQWILTAAHCFYGVE
SPKILRVYSGILNQAEIKEDTSFFGVQEIIIHDQYKMAESGYDIALLKLE
TTVNYADSQRPICLPSKGDRNVIYTDCWVTGWGYRALRDKIQNTLQKAKI
PLVTNEECQKRYRGHKITHKMICAGYREGGKDACKGDSGGPLSCKHNEVW
HLVGITSWGEGCAQRERPGVYTNVVEYVDWILEKTQA
3D structure
PDB1zhp Mutation of surface residues to promote crystallization of activated factor XI as a complex with benzamidine: an essential step for the iterative structure-based design of factor XI inhibitors.
ChainA
Resolution2.7 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H57 D102 K192 G193 D194 S195 G196
Catalytic site (residue number reindexed from 1) H44 D93 K185 G186 D187 S188 G189
Enzyme Commision number 3.4.21.27: coagulation factor XIa.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 BEN A D189 A190 C191 S195 T213 S214 W215 G216 G218 C219 D182 A183 C184 S188 T206 S207 W208 G209 G211 C212
BS02 GSH A R119 P121 I122 C123 W203 R110 P111 I112 C113 W200
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:1zhp, PDBe:1zhp, PDBj:1zhp
PDBsum1zhp
PubMed16204896
UniProtP03951|FA11_HUMAN Coagulation factor XI (Gene Name=F11)

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