Structure of PDB 1zet Chain A

Receptor sequence

>1zetA (length=388) Species: 9606 (Homo sapiens)

SRVIVHVDLDCFYAQVEMISNPELKDKPLGVQQKYLVVTCNYEARKLGVK
KLMNVRDAKEKCPQLVLVNGEDLTRYREMSYKVTELLEEFSPVVERLGFD
ENFVDLTEMVEKRLQQLQSDELSAVTVSGHVYNNQSINLLDVLHIRLLVG
SQIAAEMREAMYNQLGLTGCAGVASNKLLAKLVSGVFKPNQQTVLLPESC
QHLIHSLNHIKEIPGIGYKTAKCLEALGINSVRDLQTFSPKILEKELGIS
VAQRIQKLSFGEDNSPVILSGPPQSFSEEDSFKKCSSEVEAKNKIEELLA
SLLNRVCQDGRKPHTVRLIIRRYSSEKHYGRESRQCPIPSHVIQKLGTGN
YDVMTPMVDILMKLFRNMVNVKMPFHLTLLSVCFCNLK

3D structure

• PDB: 1zet DNA polymerases: Hoogsteen base-pairing in DNA replication?
• Chain: A
• Resolution: 2.3 Å

Enzymatic activity

• Enzyme Commision number: 2.7.7.7: DNA-directed DNA polymerase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	dna	A	K60 E97 L99 R103 P299 Q300 S301 F302 S303 E304 E305 S307 K310	K34 E71 L73 R77 P273 Q274 S275 F276 S277 E278 E279 S281 K284
BS02	dna	A	L123 G124 E127 K207 G241 K245 R343 R357 E358 S359 R360 Q361 C362 P363 L390 M394	L97 G98 E101 K181 G215 K219 R317 R331 E332 S333 R334 Q335 C336 P337 L364 M368
BS03	MG	A	D34 L35 D126	D8 L9 D100
BS04	TTP	A	L35 D36 C37 F38 Y39 T65 Y68 R71 K77 D126 K214	L9 D10 C11 F12 Y13 T39 Y42 R45 K51 D100 K188

Gene Ontology

Molecular Function

• GO:0003684 damaged DNA binding
• GO:0003887 DNA-directed DNA polymerase activity

Biological Process

• GO:0006281 DNA repair

External links

• PDB: RCSB:1zet, PDBe:1zet, PDBj:1zet
• PDBsum: 1zet
• PubMed: 16163299
• UniProt: Q9UNA4|POLI_HUMAN DNA polymerase iota (Gene Name=POLI)