Structure of PDB 1zdl Chain A

Receptor sequence

>1zdlA (length=484) Species: 10090 (Mus musculus) [Search protein sequence]

QSFDLLVIGGGSGGLACAKEAAQLGKKVAVADYVEPSPRGTKWGLGGTCV
NVGCIPKKLMHQAALLGGMIRDAHHYGWEVAQPVQHNWKTMAEAVQNHVK
SLNWGHRVQLQDRKVKYFNIKASFVDEHTVRGVDKGGKATLLSAEHIVIA
TGGRPRYPTQVKGALEYGITSDDIFWLKESPGKTLVVGASYVALECAGFL
TGIGLDTTVMMRSIPLRGFDQQMSSLVTEHMESHGTQFLKGCVPSHIKKL
PTNQLQVTWEDHASGKEDTGTFDTVLWAIGRVPETRTLNLEKAGISTNPK
NQKIIVDAQEATSVPHIYAIGDVAEGRPELTPTAIKAGKLLAQRLFGKSS
TLMDYSNVPTTVFTPLEYGCVGLSEEEAVALHGQEHVEVYHAYYKPLEFT
VADRDASQCYIKMVCMREPPQLVLGLHFLGPNAGEVTQGFALGIKCGASY
AQVMQTVGIHPTCSEEVVKLHISKRSGLEPTVTG

3D structure

PDB

1zdl Crystal structures of oxidized and reduced mitochondrial thioredoxin reductase provide molecular details of the reaction mechanism.

Chain

Resolution

3.0 Å

3D
structure

Catalytic site residues are labeled in the structure
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Enzymatic activity

Catalytic site (original residue number in PDB)	L82 C86 C91 K94 Y228 E232 G495 H497 E502 G521
Catalytic site (residue number reindexed from 1)	L45 C49 C54 K57 Y191 E195 G458 H460 E465 G484
Enzyme Commision number	1.8.1.9: thioredoxin-disulfide reductase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	FAD	A	G50 D69 Y70 G84 T85 G90 C91 K94 A159 T188 G189 R318 G358 D359 E366 L367 T368	G13 D32 Y33 G47 T48 G53 C54 K57 A122 T151 G152 R281 G321 D322 E329 L330 T331
BS02	NDP	A	A226 S227 Y228 V229 E232 R249 R254 I316 G317 E366	A189 S190 Y191 V192 E195 R212 R217 I279 G280 E329

Gene Ontology

	Molecular Function
GO:0004791	thioredoxin-disulfide reductase (NADPH) activity
GO:0005515	protein binding
GO:0016491	oxidoreductase activity
GO:0016668	oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor
GO:0042803	protein homodimerization activity
GO:0050660	flavin adenine dinucleotide binding

	Biological Process
GO:0000305	response to oxygen radical
GO:0006979	response to oxidative stress
GO:0007507	heart development
GO:0030097	hemopoiesis
GO:0045454	cell redox homeostasis
GO:0098869	cellular oxidant detoxification

	Cellular Component
GO:0005739	mitochondrion

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Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:1zdl, PDBe:1zdl, PDBj:1zdl
PDBsum	1zdl
PubMed	16217027
UniProt	Q9JLT4\|TRXR2_MOUSE Thioredoxin reductase 2, mitochondrial (Gene Name=Txnrd2)

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