Structure of PDB 1zc0 Chain A

Receptor sequence
>1zc0A (length=286) Species: 9606 (Homo sapiens) [Search protein sequence]
TPREVTLHFLRTAGHPLTRWALQRQPPSPKQLEEEFLKIPSNFVSPEDLD
IPGHASKDRYKTILPNPQSRVCLGRAQSQEDGDYINANYIRGYDGKEKVY
IATQGPMPNTVSDFWEMVWQEEVSLIVMLTQLRECVHYWPTEEETYGPFQ
IRIQDMKECPEYTVRQLTIQYQEERRSVKHILFSAWPDHQTPESAGPLLR
LVAEVEESPETAAHPGPIVVHCSAGIGRTGCFIATRIGCQQLKARGEVDI
LGIVCQLRLDRGGMIQTAEQYQFLHHTLALYAGQLP
3D structure
PDB1zc0 Structure of the hematopoietic tyrosine phosphatase (HePTP) catalytic domain: structure of a KIM phosphatase with phosphate bound at the active site.
ChainA
Resolution1.85 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) D236 C270 R276 T277 Q314
Catalytic site (residue number reindexed from 1) D188 C222 R228 T229 Q266
Enzyme Commision number 3.1.3.48: protein-tyrosine-phosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 PO4 A D236 C270 S271 A272 I274 G275 R276 Q314 D188 C222 S223 A224 I226 G227 R228 Q266
Gene Ontology
Molecular Function
GO:0004725 protein tyrosine phosphatase activity
Biological Process
GO:0006470 protein dephosphorylation
GO:0016311 dephosphorylation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:1zc0, PDBe:1zc0, PDBj:1zc0
PDBsum1zc0
PubMed16226275
UniProtP35236|PTN7_HUMAN Tyrosine-protein phosphatase non-receptor type 7 (Gene Name=PTPN7)

[Back to BioLiP]