Structure of PDB 1zbh Chain A

Receptor sequence
>1zbhA (length=289) Species: 9606 (Homo sapiens) [Search protein sequence]
DFSDPVYKEIAITNGCINRMSKEELRAKLSEFKLETRGVKDVLKKRLKNY
YKKQKLMLKESNFADSYYDYICIIDFEATCEEGNPPEFVHEIIEFPVVLL
NTHTLEIEDTFQQYVRPEINTQLSDFCISLTGITQDQVDRADTFPQVLKK
VIDLMKLKELGTKYKYSLLTDGSWDMSKFLNIQCQLSRLKYPPFAKKWIN
IRKSYGNFYKVPRSQTKLTIMLEKLGMDYDGRPNCGLDDSKNIARIAVRM
LQDGCELRINEKMHAGQLMSVSSSLPIEGTPPPQMPHFR
3D structure
PDB1zbh Structural basis for 3'-end specific recognition of histone mRNA stem-loop by 3'-exonuclease, a human nuclease that also targets siRNA
ChainA
Resolution3.0 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D134 D234 D298
Catalytic site (residue number reindexed from 1) D75 D175 D239
Enzyme Commision number 3.1.-.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna A K262 N266 R272 S329 S332 K203 N207 R213 S270 S273
BS02 rna A F61 Y66 K67 A70 N73 G74 N77 K104 K107 F2 Y7 K8 A11 N14 G15 N18 K45 K48
BS03 MG A D134 E136 D298 D75 E77 D239
BS04 AMP A D134 F135 E136 A137 C139 N143 F185 F238 D75 F76 E77 A78 C80 N84 F126 F179
Gene Ontology
Molecular Function
GO:0000175 3'-5'-RNA exonuclease activity
GO:0003676 nucleic acid binding

View graph for
Molecular Function
External links
PDB RCSB:1zbh, PDBe:1zbh, PDBj:1zbh
PDBsum1zbh
PubMed
UniProtQ8IV48|ERI1_HUMAN 3'-5' exoribonuclease 1 (Gene Name=ERI1)

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