Structure of PDB 1zaf Chain A

Receptor sequence

>1zafA (length=228) Species: 9606 (Homo sapiens) [Search protein sequence]

LSPEQLVLTLLEAEPPHVLISRPSAPFTEASMMMSLTKLADKELVHMISW
AKKIPGFVELSLFDQVRLLESCWMEVLMMGLMWRSIDHPGKLIFAPDLVL
DRDEGKCVEGILEIFDMLLATTSRFRELKLQHKEYLCVKAMILLNSAMDS
SRKLAHLLNAVTDALVWVIAKSGISSQQQSMRLANLLMLLSHVRHASNKG
MEHLLNMKCKNVVPVYDLLLEMLNAHVL

3D structure

PDB

1zaf Estrogen receptor ligands: design and synthesis of new 2-arylindene-1-ones

Chain

Resolution

2.2 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	A	I310 K314 V328 E332 D489 E493	I48 K52 V66 E70 D217 E221
BS02	789	A	M295 E305 L339 F356 H475 L476	M33 E43 L77 F94 H203 L204	MOAD: ic50=20nM PDBbind-CN: -logKd/Ki=7.70,IC50=20nM BindingDB: IC50=20nM

External links

PDB	RCSB:1zaf, PDBe:1zaf, PDBj:1zaf
PDBsum	1zaf
PubMed	15876535
UniProt	Q92731\|ESR2_HUMAN Estrogen receptor beta (Gene Name=ESR2)

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