Structure of PDB 1z95 Chain A

Receptor sequence
>1z95A (length=238) Species: 9606 (Homo sapiens) [Search protein sequence]
IFLNVLEAIEPGVVCAGHDNNQPDSFAALLSSLNELGERQLVHVVKWAKA
LPGFRNLHVDDQMAVIQYSLMGLMVFAMGWRSFTNVNSRMLYFAPDLVFN
EYRMHKSRMYSQCVRMRHLSQEFGWLQITPQEFLCMKALLLFSIIPVDGL
KNQKFFDELRMNYIKELDRIIACSRRFYQLTKLLDSVQPIARELHQFTFD
LLIKSHMVSVDFPEMMAEIISVQVPKILSGKVKPIYFH
3D structure
PDB1z95 Structural basis for antagonism and resistance of bicalutamide in prostate cancer.
ChainA
Resolution1.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 198 A L704 N705 L707 Q711 M742 M745 V746 M749 F764 T877 M895 I899 L33 N34 L36 Q40 M71 M74 V75 M78 F93 T198 M216 I220 MOAD: Ki=76nM
PDBbind-CN: -logKd/Ki=7.12,Ki=76nM
BindingDB: IC50=248nM,Ki=509nM
External links
PDB RCSB:1z95, PDBe:1z95, PDBj:1z95
PDBsum1z95
PubMed15833816
UniProtP10275|ANDR_HUMAN Androgen receptor (Gene Name=AR)

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