Structure of PDB 1z8g Chain A

Receptor sequence
>1z8gA (length=366) Species: 9606 (Homo sapiens) [Search protein sequence]
EPLYPVQVSSADARLMVFDKTEGTWRLLCSSRSNARVAGLSCEEMGFLRA
LTHSELDVRTAGAAGTSGFFCVDEGRLPHTQRLLEVISVCDCPRGRFLAA
ICQDCGRRKLPIVGGRDTSLGRWPWQVSLRYDGAHLCGGSLLSGDWVLTA
AHCFPERNRVLSRWRVFAGAVAQASPHGLQLGVQAVVYHGGYLPFRDPNS
EENSNDIALVHLSSPLPLTEYIQPVCLPAAGQALVDGKICTVTGWGNTQY
YGQQAGVLQEARVPIISNDVCNGADFYGNQIKPKMFCAGYPEGGIDACQG
DSGGPFVCEDSISRTPRWRLCGIVSWGTGCALAQKPGVYTKVSDFREWIF
QAIKTHSEASGMVTQL
3D structure
PDB1z8g Hepatocyte growth factor is a preferred in vitro substrate for human hepsin, a membrane-anchored serine protease implicated in prostate and ovarian cancers
ChainA
Resolution1.55 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H203 D257 Q350 G351 D352 S353 G354
Catalytic site (residue number reindexed from 1) H152 D206 Q299 G300 D301 S302 G303
Enzyme Commision number 3.4.21.106: hepsin.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A H203 Y243 E252 N254 Y301 D347 A348 C349 Q350 S353 S376 W377 G378 T379 H152 Y192 E201 N203 Y250 D296 A297 C298 Q299 S302 S325 W326 G327 T328
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0070008 serine-type exopeptidase activity
Biological Process
GO:0006508 proteolysis
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1z8g, PDBe:1z8g, PDBj:1z8g
PDBsum1z8g
PubMed15839837
UniProtP05981|HEPS_HUMAN Serine protease hepsin (Gene Name=HPN)

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