Structure of PDB 1z5w Chain A

Receptor sequence
>1z5wA (length=409) Species: 9606 (Homo sapiens) [Search protein sequence]
PREIITLQLGQCGNQIGFEFWKQLCAEHGISPEAITDRKDVFFYQADDEH
YIPRAVLLDLEPRVIHSILNSPYAKLYNPENIYLSGNNWASGFSQGEKIH
EDIFDIIDREADGSDSLEGFVLCHSIAGGTGSGLGSYLLERLNDRYPKKL
VQTYSVFPNQSDVVVQPYNSLLTLKRLTQNADCLVVLDNTALNRIATDRL
HIQNPSFSQINQLVSTIMSASTTTLRYPGYMNNDLIGLIASLIPTPRLHF
LMTGYTPLTTDSVRKTTVLDVMRRLLQPKNVMVSTGTNHCYIAILNIIQG
EVDPTQVHKSLQRIRERKLANFIPWGPASIQVALSRKSPYRVSGLMMANH
TSISSLFERTCRQYDKLRKREAFLEQFRKEDMFKDNFDEMDTSREIVQQL
IDEYHAATR
3D structure
PDB1z5w Insights into microtubule nucleation from the crystal structure of human gamma-tubulin.
ChainA
Resolution3.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GTP A Q12 C13 Q16 N102 S140 G143 G144 T145 P173 N207 F225 N229 Q11 C12 Q15 N87 S125 G128 G129 T130 P158 N189 F207 N211
Gene Ontology
Molecular Function
GO:0005200 structural constituent of cytoskeleton
GO:0005515 protein binding
GO:0005525 GTP binding
GO:0042802 identical protein binding
Biological Process
GO:0000070 mitotic sister chromatid segregation
GO:0000212 meiotic spindle organization
GO:0000226 microtubule cytoskeleton organization
GO:0000278 mitotic cell cycle
GO:0007017 microtubule-based process
GO:0007020 microtubule nucleation
GO:0007052 mitotic spindle organization
GO:0031122 cytoplasmic microtubule organization
Cellular Component
GO:0000242 pericentriolar material
GO:0000794 condensed nuclear chromosome
GO:0000930 gamma-tubulin complex
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0005814 centriole
GO:0005819 spindle
GO:0005827 polar microtubule
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0005874 microtubule
GO:0005876 spindle microtubule
GO:0005881 cytoplasmic microtubule
GO:0005929 cilium
GO:0015630 microtubule cytoskeleton
GO:0031252 cell leading edge
GO:0036064 ciliary basal body
GO:0043005 neuron projection
GO:0045177 apical part of cell
GO:0055037 recycling endosome
GO:0097730 non-motile cilium
GO:1990498 mitotic spindle microtubule

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1z5w, PDBe:1z5w, PDBj:1z5w
PDBsum1z5w
PubMed15917813
UniProtP23258|TBG1_HUMAN Tubulin gamma-1 chain (Gene Name=TUBG1)

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