Structure of PDB 1z5h Chain A

Receptor sequence
>1z5hA (length=780) Species: 2303 (Thermoplasma acidophilum) [Search protein sequence]
MEVEKYDLTLDFDIQKRTFNGTETITADAGDIVLDAVGLQINWMKVNGRD
TAFTYDGQTVRAPGDSQPQKIEISFAGKVSDSLSGIYYAGRENGMITTHF
EATDARRMFPCVDHPAYKAVFAITVVIDKDYDAISNMPPKRIEVSERKVV
EFQDTPRMSTYLLYVGIGKFRYEYEKYRDIDLILASLKDIRSKYPLDMAR
KSVEFYENYFGIPYALPKMHLISVPEFGAGAMENWGAITFREIYMDIAEN
SAVTVKRNSANVIAHEIAHQWFGDLVTMKWWNDLWLNESFATFMSYKTMD
TLFPEWSFWGDFFVSRTSGALRSDSLKNTHPIEVDVRDPDEISQIFDEIS
YGKGASILRMIEDYAGYEEFRKGISKYLNDHKFGNAEGSDLWTAIEDVSG
KPVKRVMEYWIKNPGYPVIKLKRNGRKITMYQTRFLLNGEEEGRWPVPVN
IKKKDGVERILLEDEASIEADGLIKINADSAGFYRVLYDDATFSDVMGHY
RDLSPLDRIGLVDDLFAFLLSGHIDPETYRQRIRNFFDDEDHNVITAIVG
QMEYLRMLTHAFDDDARAFCRSRMQFLTGKQDENLKIALGRVSRLYVMVD
ESYAEEMSKLFKDFDSAEPEMRSSIATAYALVTGDLKGLLEKFRSVDRDE
DRVRIISAFGKLKSNTDLSTVYGMVEKTEIKKQDMISFFSSALETLPGRE
FIFANLDRIIRLVIRYFTGNRTASRTVEMMIPVIGLDHPDAEDIVRNIGS
KNISMGLAKGIEMLAVNRKLVERIRQTAVK
3D structure
PDB1z5h Crystal Structures of the Tricorn Interacting Factor F3 from Thermoplasma acidophilum, a Zinc Aminopeptidase in Three Different Conformations
ChainA
Resolution2.3 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) E233 H265 E266 H269 E288 S343 Y351
Catalytic site (residue number reindexed from 1) E233 H265 E266 H269 E288 S343 Y351
Enzyme Commision number 3.4.11.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A H265 H269 E288 H265 H269 E288
Gene Ontology
Molecular Function
GO:0004177 aminopeptidase activity
GO:0008237 metallopeptidase activity
GO:0008270 zinc ion binding
GO:0042277 peptide binding
GO:0046872 metal ion binding
GO:0070006 metalloaminopeptidase activity
Biological Process
GO:0006508 proteolysis
GO:0043171 peptide catabolic process
Cellular Component
GO:0005737 cytoplasm

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Cellular Component
External links
PDB RCSB:1z5h, PDBe:1z5h, PDBj:1z5h
PDBsum1z5h
PubMed15893768
UniProtO93655|TRF3_THEAC Tricorn protease-interacting factor F3 (Gene Name=trf3)

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