Structure of PDB 1z5b Chain A

Receptor sequence
>1z5bA (length=466) Species: 2286 (Saccharolobus shibatae) [Search protein sequence]
KEKFTSLSPAEFFKRNPELAGFPNPARALYQTVRELIENSLDATDVHGIL
PNIKITIDLIDDARQIYKVNVVDNGIGIPPQEVPNAFGRVLYSSKYVNRQ
TRGMYGLGVKAAVLYSQMHQDKPIEIETSPVNSKRIYTFKLKIDINKNEP
IIVERGSVENTRGFHGTSVAISIPGDWPKAKSRIYEYIKRTYIITPYAEF
IFKDPEGNVTYYPRLTNKIPKPPQEVKPHPYGVDREEIKILINNLKRDYT
IKEFLVNEFQSIGDTTADKILELAGLKPNKKVKNLTEEEITRLVETFKKY
EDFRSPSADSLSVIGEDLIELGLKKIFNPDFAASITRKPKAYQGHPFIVE
AGVAFGGSIPVGEEPIVLRYANKIPLIYDEKSDVIWKVVEELDWKRYGIE
SDQYQMVVMVHLCSTKIPYKSAGKESIAEVEDIEKEIKNALMEVARKLKQ
YLSEKRKEQEAKKKLL
3D structure
PDB1z5b Structural dissection of ATP turnover in the prototypical GHL ATPase TopoVI.
ChainA
Resolution2.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 5.6.2.2: DNA topoisomerase (ATP-hydrolyzing).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ALF A E38 G106 M107 Y108 L110 G111 K427 E35 G103 M104 Y105 L107 G108 K424
BS02 ADP A N42 A46 I81 A89 S96 S97 K98 G109 V112 K113 N39 A43 I78 A86 S93 S94 K95 G106 V109 K110
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003918 DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
GO:0005524 ATP binding
Biological Process
GO:0006265 DNA topological change

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Molecular Function
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Biological Process
External links
PDB RCSB:1z5b, PDBe:1z5b, PDBj:1z5b
PDBsum1z5b
PubMed15939019
UniProtO05207|TOP6B_SACSH Type 2 DNA topoisomerase 6 subunit B (Gene Name=top6B)

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