Structure of PDB 1z57 Chain A

Receptor sequence
>1z57A (length=333) Species: 9606 (Homo sapiens) [Search protein sequence]
SMHLICQSGDVLSARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKN
VDRYCEAARSEIQVLEHLNTTDPNSTFRCVQMLEWFEHHGHICIVFELLG
LSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLHSNKLTHTDLKPENIL
FVQSDYTEAYNRDERTLINPDIKVVDFGSATYDDEHHSTLVSTRHYRAPE
VILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLP
KHMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRACKPLKEFMLSQDVEHER
LFDLIQKMLEYDPAKRITLREALKHPFFDLLKK
3D structure
PDB1z57 Kinase domain insertions define distinct roles of CLK kinases in SR protein phosphorylation.
ChainA
Resolution1.7 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D288 K290 N293 D325 T342
Catalytic site (residue number reindexed from 1) D143 K145 N148 D176 T193
Enzyme Commision number 2.7.12.1: dual-specificity kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 DBQ A V175 A189 K191 F241 L244 L295 V324 D325 V30 A44 K46 F96 L99 L150 V175 D176
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:1z57, PDBe:1z57, PDBj:1z57
PDBsum1z57
PubMed19278650
UniProtP49759|CLK1_HUMAN Dual specificity protein kinase CLK1 (Gene Name=CLK1)

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