Structure of PDB 1z4x Chain A

Receptor sequence
>1z4xA (length=448) [Search protein sequence]
INDNRYINGINQFYFSIAEGRNLTLGPLLNMPSFIPTATTPEGCTRIPSF
SLTKTHWCYTHNVILNGCQDHVSSNQFVSMGIIEPTSAGFPFFRTLKTLY
LSDGVNRKSCSISTVPGGCMMYCFVSTQPERDDYFSAAPPEQRIIIMYYN
DTIVERIINPPGVLDVWATLNPGTGSGVYYLGWVLFPIYGGVIKGTSLWN
NQANKYFIPQMVAALCSQNQATQVQNAKSSYYSSWFGNRMIQSGILACPL
RQDLTNECLVLPFSNDQVLMGAEGRLYMYGDSVYYYQRSNSWWPMTMLYK
VTITFTNGQPSAISAQNVPTQQVPRPGTGDCSATNRCPGFCLTGVYADAW
LLTNPSSTSTFGSEATFTGSYLNTATQRINPTMYIANNTQIISSQQFGSS
GQEAAYGHTTCFRDTGSVMVYCIYIIELSSSLLGQFQIVPFIRQVTLS
3D structure
PDB1z4x Structural studies of the parainfluenza virus 5 hemagglutinin-neuraminidase tetramer in complex with its receptor, sialyllactose.
ChainA
Resolution2.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.2.1.18: exo-alpha-sialidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SIA A R163 E247 Y306 E390 R405 R495 Y523 R46 E130 Y189 E273 R288 R378 Y406
BS02 CA A D250 S253 A255 P256 A285 D133 S136 A138 P139 A168
Gene Ontology
Molecular Function
GO:0004308 exo-alpha-sialidase activity
GO:0016787 hydrolase activity
GO:0042802 identical protein binding
GO:0046789 host cell surface receptor binding
Biological Process
GO:0019058 viral life cycle
GO:0019062 virion attachment to host cell
GO:0046718 symbiont entry into host cell
GO:0046761 viral budding from plasma membrane
Cellular Component
GO:0016020 membrane
GO:0019031 viral envelope
GO:0020002 host cell plasma membrane
GO:0055036 virion membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1z4x, PDBe:1z4x, PDBj:1z4x
PDBsum1z4x
PubMed15893670
UniProtP04850|HN_PIV5 Hemagglutinin-neuraminidase (Gene Name=HN)

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