Structure of PDB 1z4k Chain A

Receptor sequence
>1z4kA (length=194) Species: 9606 (Homo sapiens) [Search protein sequence]
RALRVLVNMDGVLADFEGGFLRKFRARFPDQPFIALEDRRGFWVSEQYGR
LRPGLSEKAISIWESKNFFFELEPLPGAVEAVKEMASLQNTDVFICTSPI
KMFKYCPYEKYAWVEKYFGPDFLEQIVLTRDKTVVSADLLIDDRPDITGA
EPTPSWEHVLFTACHNQHLQLQPPRRRLHSWADDWKAILDSKRP
3D structure
PDB1z4k Structural basis for substrate specificity of the human mitochondrial deoxyribonucleotidase
ChainA
Resolution1.75 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) N41 D43 D176
Catalytic site (residue number reindexed from 1) N8 D10 D143
Enzyme Commision number 3.1.3.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG A N41 D43 D176 N8 D10 D143
BS02 T3P A N41 M42 D43 F49 W76 V77 W96 T130 S131 P132 K143 N8 M9 D10 F16 W43 V44 W63 T97 S98 P99 K110
Gene Ontology
Molecular Function
GO:0008253 5'-nucleotidase activity
Biological Process
GO:0009264 deoxyribonucleotide catabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:1z4k, PDBe:1z4k, PDBj:1z4k
PDBsum1z4k
PubMed16004879
UniProtQ9NPB1|NT5M_HUMAN 5'(3')-deoxyribonucleotidase, mitochondrial (Gene Name=NT5M)

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