Structure of PDB 1z3h Chain A

Receptor sequence
>1z3hA (length=925) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence]
SDLETVAKFLAESVIASTAKTSERNLRQLETQDGFGLTLLHVIASTNLPL
STRLAGALFFKNFIKRKWVDENGNHLLPANNVELIKKEIVPLMISLPNNL
QVQIGEAISSIADSDFPDRWPTLLSDLASRLSNDDMVTNKGVLTVAHSIF
KRWRPLFRSDELFLEIKLVLDVFTAPFLNLLKTVDEQITANENNKASLNI
LFDVLLVLIKLYYDFNCQDIPEFFEDNIQVGMGIFHKYLSYSNPLLEDPD
ETEHASVLIKVKSSIQELVQLYTTRYEDVFGPMINEFIQITWNLLTSISN
QPKYDILVSKSLSFLTAVTRIPKYFEIFNNESAMNNITEQIILPNVTLRE
EDVELFEDDPIEYIRRDLEGSDTDTRRRACTDFLKELKEKNEVLVTNIFL
AHMKGFVDQYMSDPSKNWKFKDLYIYLFTALAINGNITNAGVSSTNNLLN
VVDFFTKEIAPDLTSNNIPHIILRVDAIKYIYTFRNQLTKAQLIELMPIL
ATFLQTDEYVVYTYAAITIEKILTIRESSNSTEILLKNLIALILKHGSSP
EKLAENEFLMRSIFRVLQTSEDSIQPLFPQLLAQFIEIVTIMAKNPSNPR
FTHYTFESIGAILNYTQRQNLPLLVDSMMPTFLTVFSEDIQEFIPYVFQI
IAFVVEQSATIPESIKPLAQPLLAPNVWELKGNIPAVTRLLKSFIKTDSS
IFPDLVPVLGIFQRLIASKAYEVHGFDLLEHIMLLIDMNRLRPYIKQIAV
LLLQRLQNSKTERYVKKLTVFFGLISNKLGSDFLIHFIDEVQDGLFQQIW
GNFIITTLPTIGNLLDRKIALIGVLNMVINGQFFQSKYPTLISSTMNSII
ETASSQSGSHFSKLVSISEKPFDPLPEIDVNNGVRLYVAEALNKYNAISG
NTFLNTILPQLTQENQVKLNQLLVG
3D structure
PDB1z3h The structure of the nuclear export receptor cse1 in its cytosolic state reveals a closed conformation incompatible with cargo binding
ChainA
Resolution3.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG A D796 H800 D782 H786
Gene Ontology
Molecular Function
GO:0005049 nuclear export signal receptor activity
GO:0005515 protein binding
GO:0031267 small GTPase binding
Biological Process
GO:0006606 protein import into nucleus
GO:0006611 protein export from nucleus
GO:0006886 intracellular protein transport
GO:0015031 protein transport
GO:0046827 positive regulation of protein export from nucleus
GO:0051170 import into nucleus
GO:0051301 cell division
GO:0061015 snRNA import into nucleus
Cellular Component
GO:0005634 nucleus
GO:0005635 nuclear envelope
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0032991 protein-containing complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1z3h, PDBe:1z3h, PDBj:1z3h
PDBsum1z3h
PubMed15866177
UniProtP33307|CSE1_YEAST Importin alpha re-exporter (Gene Name=CSE1)

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