Structure of PDB 1z3c Chain A

Receptor sequence
>1z3cA (length=252) Species: 6035 (Encephalitozoon cuniculi) [Search protein sequence]
SKTINIRNANNFIKACLIRLYTKRGDSVLDLGCGKGGDLLKYERAGIGEY
YGVDIAEVSINDARVRARNMKRRFKVFFRAQDSYGRHMDLGKEFDVISSQ
FSFHYAFSTSESLDIAQRNIARHLRPGGYFIMTVPSRDVILERYKQGRMS
NDFYKIELEKMEDVPMESVREYRFTLLDSVNNCIEYFVDFTRMVDGFKRL
GLSLVERKGFIDFYEDEGRRNPELSKKMGLGCLTREESEVVGIYEVVVFR
KL
3D structure
PDB1z3c Encephalitozoon cuniculi mRNA cap (guanine N-7) methyltransferase: methyl acceptor specificity, inhibition BY S-adenosylmethionine analogs, and structure-guided mutational analysis.
ChainA
Resolution2.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.56: mRNA (guanine-N(7))-methyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SA8 A K54 G72 D94 I95 D122 S123 Y124 Q140 F141 S142 Y145 K14 G32 D54 I55 D82 S83 Y84 Q100 F101 S102 Y105 MOAD: ic50=100uM
PDBbind-CN: -logKd/Ki=4.00,IC50=100uM
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0004482 mRNA 5'-cap (guanine-N7-)-methyltransferase activity
GO:0008168 methyltransferase activity
Biological Process
GO:0006370 7-methylguanosine mRNA capping
GO:0032259 methylation
GO:0106005 RNA 5'-cap (guanine-N7)-methylation
Cellular Component
GO:0005634 nucleus

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Biological Process
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Cellular Component
External links
PDB RCSB:1z3c, PDBe:1z3c, PDBj:1z3c
PDBsum1z3c
PubMed15760890
UniProtQ8SR66|MCES_ENCCU mRNA cap guanine-N7 methyltransferase (Gene Name=ABD1)

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