Structure of PDB 1z26 Chain A

Receptor sequence
>1z26A (length=716) Species: 2261 (Pyrococcus furiosus) [Search protein sequence]
SMKAIVVINLVKINKKIIPDKIYVYRLYSIYRLAYENVGIVIDPENLIIA
TTKELEYEGEFIPEGEISFSELRNDYQSKLVLRLLKENGIGEYELSKLLR
KFRKPKTFGDYKVIPSVEMSVIKHDEDFYLVIHIIHQIQSMKTLWELVNK
DPKELEEFLMTHKENLMLKDIASPLKTVYKPCFEEYTKKPKLDHNQEIVK
YWYNYHIERYWNTPEAKLEFYRKFGQVDLKQPAILAKFASKNYKIYLLPQ
LVVPTYNAEQLAKEILEYTKLMPEERKELLENILAEVDSDIIDKSLSEIE
VEKIAQELENKIRVRDDKGNSVPISQLLWTNYSRKYPVILPYEVPEKFRK
IREIPMFIILDSGLLADIQNFATNEFRELVKSMYYSLAKKYKEKVITEDL
NSDKGIIEVVEQVSSFMKGKELGLAFIAARNKLSSEKFEEIKRRLFNLNV
ISQVVNEDTLKNKRDKYDRNRLDLFVRHNLLFQVLSKLGVKYYVLDYRFN
YDYIIGIDVAPMKRSEGYIGGSAVMFDSQGYIRKIVPIKIGEQRGESVDM
NEFFKEMVDKFKEFNIKLDNKKILLLRDGRITNNEEEGLKYISEMFDIEV
VTMDVIKNHPVRAFANMKMYFNLGGAIYLIPHKLKQAKGTPIPIKLAKKR
IIKNGKVEKQSITRQDVLDIFILTRLNYGSIRLPAPVHYAHKFANAIRNE
WKIKEEFLAEGFLYFV
3D structure
PDB1z26 Purified Argonaute2 and an siRNA form recombinant human RISC.
ChainA
Resolution2.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.24.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 WO4 A E329 K668 H682 K683 E309 K618 H632 K633
BS02 WO4 A Q326 E329 K668 Q306 E309 K618
BS03 WO4 A N8 I143 H144 I145 R296 R662 F664 N9 I132 H133 I134 R276 R612 F614
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003723 RNA binding
GO:0004519 endonuclease activity
GO:0004520 DNA endonuclease activity
GO:0030145 manganese ion binding
GO:0046872 metal ion binding
Biological Process
GO:0006259 DNA metabolic process
GO:0044355 clearance of foreign intracellular DNA

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Molecular Function
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Biological Process
External links
PDB RCSB:1z26, PDBe:1z26, PDBj:1z26
PDBsum1z26
PubMed15800637
UniProtQ8U3D2|AGO_PYRFU Protein argonaute (Gene Name=ago)

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