Structure of PDB 1z1g Chain A

Receptor sequence

>1z1gA (length=349) Species: 10710 (Lambdavirus lambda)

ERRDLPPNLYIRNNGYYCYRDPRTGKEFGLGRDRRIAITEAIQANIELFS
GHKHKPLTARINSDNSVTLHSWLDRYEKILASRGIKQKTLINYMSKIKAI
RRGLPDAPLEDITTKEIAAMLNGYIDEGKAASAKLIRSTLSDAFREAIAE
GHITTNHVAATRAAKSEVRRSRLTADEYLKIYQAAESSPCWLRLAMELAV
VTGQRVGDLCEMKWSDIVDGYLYVEQSKTGVKIAIPTALHIDALGISMKE
TLDKCKEILGGETIIASTRREPLSSGTVSRYFMRARKASGLSFEGDPPTF
HELRSLSARLYEKQISDKFAQHLLGHKSDTMASQFRDDRGREWDKIEIK

3D structure

• PDB: 1z1g A structural basis for allosteric control of DNA recombination by lambda integrase.
• Chain: A
• Resolution: 4.4 Å

Enzymatic activity

• Enzyme Commision number: 2.7.7.-
  3.1.-.-

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	dna	A	R109 K136 S139 V175 R176 R177 R212 K235 T236 F342	R102 K129 S132 V168 R169 R170 R205 K228 T229 F335
BS02	dna	A	R90 K93 T96 N99 Y100 K172 G214 S234 K235 S286 R287 R293 T306 F307 H308	R83 K86 T89 N92 Y93 K165 G207 S227 K228 S279 R280 R286 T299 F300 H301
BS03	dna	A	R19 Y23 E34 F35 G36	R12 Y16 E27 F28 G29
BS04	dna	A	R10 L12 P14 Y17 R19 N20 R27 P29	R3 L5 P7 Y10 R12 N13 R20 P22

Gene Ontology

Molecular Function

• GO:0003677 DNA binding
• GO:0008907 integrase activity
• GO:0016740 transferase activity
• GO:0016787 hydrolase activity

Biological Process

• GO:0006310 DNA recombination
• GO:0015074 DNA integration
• GO:0032359 provirus excision
• GO:0044826 viral genome integration into host DNA
• GO:0046718 symbiont entry into host cell
• GO:0075713 establishment of integrated proviral latency

External links

• PDB: RCSB:1z1g, PDBe:1z1g, PDBj:1z1g
• PDBsum: 1z1g
• PubMed: 15973401
• UniProt: P03700|VINT_LAMBD Integrase (Gene Name=int)