Structure of PDB 1z19 Chain A

Receptor sequence

>1z19A (length=273) Species: 10710 (Lambdavirus lambda)

MTLHSWLDRYEKILASRGIKQKTLINYMSKIKAIRRGLPDAPLEDITTKE
IAAMLNGYIDEGKAASAKLIRSTLSDAFREAIAEGHITTNHVAATRAAKS
KVRRSRLTADEYLKIYQAAESSPCWLRLAMELAVVTGQRVGDLCEMKWSD
IVDGYLYVEQSKTGVKIAIPTALHIDALGISMKETLDKCKEILGGETIIA
STRREPLSSGTVSRYFMRARKASGLSFEGDPPTFHELRSLSARLYEKQIS
DKFAQHLLGHKSDTMEWDKIEIK

3D structure

• PDB: 1z19 A structural basis for allosteric control of DNA recombination by lambda integrase.
• Chain: A
• Resolution: 2.8 Å

Enzymatic activity

• Enzyme Commision number: 2.7.7.-
  3.1.-.-

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	dna	A	I92 K93 K95 T96 N99 Y100 R177 V213 G214 S234 K235 S286 R287 M290 R293 T306 H308	I19 K20 K22 T23 N26 Y27 R104 V140 G141 S161 K162 S213 R214 M217 R220 T233 H235
BS02	dna	A	K136 A138 S139 V175 R176 R177 W198 R212 K235 S274 T275 L280 S281 T284 Y288 H308 R311 H333 K334 M338	K63 A65 S66 V102 R103 R104 W125 R139 K162 S201 T202 L207 S208 T211 Y215 H235 R238 H260 K261 M265

Gene Ontology

Molecular Function

• GO:0003677 DNA binding

Biological Process

• GO:0006310 DNA recombination
• GO:0015074 DNA integration

External links

• PDB: RCSB:1z19, PDBe:1z19, PDBj:1z19
• PDBsum: 1z19
• PubMed: 15973401
• UniProt: P03700|VINT_LAMBD Integrase (Gene Name=int)