Structure of PDB 1yyz Chain A

Receptor sequence
>1yyzA (length=326) Species: 9823 (Sus scrofa) [Search protein sequence]
IVTLTRFVMEEGRKARGTGEMTQLLNSLCTAVKAISTAVRKAGILHLYGI
AGSTNVTGDQVKKLDVLSNDLVINVLKSSFATCVLVSEEDKNAIIVEPEK
RGKYVVCFDPLDGSSNIDCLVSIGTIFGIYRKNSTDEPSEKDALQPGRNL
VAAGYALYGSATMLVLAMVNGVNCFMLDPAIGEFILVDRDVKIKKKGSIY
SINEGYAKEFDPAITEYIQRKKFPPDNSAPYGARYVGSMVADVHRTLVYG
GIFMYPANKKSPKGKLRLLYECNPMAYVMEKAGGLATTGKEAVLDIVPTD
IHQRAPIILGSPEDVTELLEIYQKHA
3D structure
PDB1yyz R-state AMP complex reveals initial steps of the quaternary transition of fructose-1,6-bisphosphatase.
ChainA
Resolution1.85 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D68 D74 E97 E98 D118 L120 D121 E280
Catalytic site (residue number reindexed from 1) D59 D65 E88 E89 D109 L111 D112 E271
Enzyme Commision number 3.1.3.11: fructose-bisphosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 F6P A D121 N212 Y215 Y244 G246 M248 Y264 K274 R276 D112 N203 Y206 Y235 G237 M239 Y255 K265 R267
BS02 MG A E97 D118 L120 E88 D109 L111
BS03 MG A D118 D121 E280 D109 D112 E271
BS04 AMP A V17 E20 G21 A24 T27 E29 M30 Y113 R140 M177 V8 E11 G12 A15 T18 E20 M21 Y104 R131 M168 MOAD: Kd=2.4uM
BindingDB: IC50=1300nM
Gene Ontology
Molecular Function
GO:0016208 AMP binding
GO:0016787 hydrolase activity
GO:0016791 phosphatase activity
GO:0042132 fructose 1,6-bisphosphate 1-phosphatase activity
GO:0042578 phosphoric ester hydrolase activity
GO:0042802 identical protein binding
GO:0046872 metal ion binding
GO:0048029 monosaccharide binding
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0005986 sucrose biosynthetic process
GO:0006000 fructose metabolic process
GO:0006002 fructose 6-phosphate metabolic process
GO:0006094 gluconeogenesis
GO:0006111 regulation of gluconeogenesis
GO:0016311 dephosphorylation
GO:0030308 negative regulation of cell growth
GO:0030388 fructose 1,6-bisphosphate metabolic process
GO:0045820 negative regulation of glycolytic process
GO:0046580 negative regulation of Ras protein signal transduction
GO:0071286 cellular response to magnesium ion
GO:0071466 cellular response to xenobiotic stimulus
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Cellular Component
External links
PDB RCSB:1yyz, PDBe:1yyz, PDBj:1yyz
PDBsum1yyz
PubMed15767255
UniProtP00636|F16P1_PIG Fructose-1,6-bisphosphatase 1 (Gene Name=FBP1)

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