Structure of PDB 1yyn Chain A

Receptor sequence
>1yynA (length=441) Species: 1513 (Clostridium tetani) [Search protein sequence]
EDIDVILKKSTILNLDINNDIISDISGFNSSVITYPDAQLVPGINGKAIH
LVNNESSEVIVHKAMDIEYNDMFNNFTVSFWLRVPKVSASHLEQYGTNEY
SIISSMKKHSLSIGSGWSVSLKGNNLIWTLKDSAGEVRQITFRDLPDKFN
AYLANKWVFITITNDRLSSANLYINGVLMGSAEITGLGAIREDNNITLKL
DRCNNNNQYVSIDKFRIFCKALNPKEIEKLYTSYLSITFLRDFWGNPLRY
DTEYYLIPVASSSKDVQLKNITDYMYLTNAPSYTNGKLNIYYRRLYNGLK
FIIKRYTPNNEIDSFVKSGDFIKLYVSYNNNEHIVGYPKDGNAFNNLDRI
LRVGYNAPGIPLYKKMEAVKLRDLKTYSVQLKLYDDKNASLGLVGTHNGQ
IGNDPNRDILIASNWYFNHLKDKILGCDWYFVPTDEGWTND
3D structure
PDB1yyn Common binding site for disialyllactose and tri-peptide in C-fragment of tetanus neurotoxin
ChainA
Resolution2.3 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) A922 K996
Catalytic site (residue number reindexed from 1) A48 K122
Enzyme Commision number 3.4.24.68: tentoxilysin.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SIA A D1147 N1216 R1226 I1275 D273 N342 R352 I401
BS02 SIA A D1214 N1216 R1226 Y1229 D340 N342 R352 Y355
Gene Ontology
Cellular Component
GO:0005576 extracellular region

View graph for
Cellular Component
External links
PDB RCSB:1yyn, PDBe:1yyn, PDBj:1yyn
PDBsum1yyn
PubMed16104015
UniProtP04958|TETX_CLOTE Tetanus toxin (Gene Name=tetX)

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