Structure of PDB 1yy4 Chain A

Receptor sequence

>1yy4A (length=225) Species: 9606 (Homo sapiens) [Search protein sequence]

LSPEQLVLTLLEAEPPHVLISRPSAPFTEASMMMSLTKLADKELVHMISW
AKKIPGFVELSLFDQVRLLESCWMEVLMMGLMWRSIDHPGKLIFAPDLVL
DRDEGKCVEGILEIFDMLLATTSRFRELKLQHKEYLCVKAMILLNSSMDS
SRKLAHLLNAVTDALVWVIAKSGISSQQQSMRLANLLMLLSHVRHASNKG
MEHLLNMKCKNVVPVYDLLLEMLNA

3D structure

PDB

1yy4 ERbeta ligands. 3. Exploiting two binding orientations of the 2-phenylnaphthalene scaffold to achieve ERbeta selectivity

Chain

Resolution

2.7 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	A	I310 K314 V328 D489 E493	I48 K52 V66 D217 E221
BS02	4NA	A	M295 E305 L339 I373 H475 L476	M33 E43 L77 I111 H203 L204	PDBbind-CN: -logKd/Ki=8.60,IC50=2.52nM BindingDB: IC50=2.52nM

External links

PDB	RCSB:1yy4, PDBe:1yy4, PDBj:1yy4
PDBsum	1yy4
PubMed	15943471
UniProt	Q92731\|ESR2_HUMAN Estrogen receptor beta (Gene Name=ESR2)

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