Structure of PDB 1yvz Chain A

Receptor sequence
>1yvzA (length=548) [Search protein sequence]
SMSYSWTGALITPCSPEEEKLPINPLSNSLLRYHNKVYCTTSKSASLRAK
KVTFDRMQVLDAYYDSVLKDIKLAASKVSARLLTLEEACQLTPPHSARSK
YGFGAKEVRSLSGRAVNHIKSVWKDLLEDSQTPIPTTIMAKNEVFCVDPT
KGGKKAARLIVYPDLGVRVCEKMALYDVTQKLPQAVMGASYGFQYSPAQR
VEFLLKAWAEKKDPMGFSYDTRCFDSTVTERDIRTEESIYQACSLPEEAR
TAIHSLTERLYVGGPMFNSKGQSCGYRRCRASGVLTTSMGNTITCYVKAL
AACKAAGIVAPTMLVCGDDLVVISESQGTEEDERNLRAFTEAMTRYSAPP
GDPPRPEYDLELITSCSSNVSVALGPQGRRRYYLTRDPTTPIARAAWETV
RHSPVNSWLGNIIQYAPTIWVRMVLMTHFFSILMAQDTLDQNLNFEMYGS
VYSVSPLDLPAIIERLHGLDAFSLHTYTPHELTRVASALRKLGAPPLRAW
KSRARAVRASLISRGGRAAVCGRYLFNWAVKTKLKLTPLPEARLLDLS
3D structure
PDB1yvz Crystal structures of the RNA dependent RNA polymerase genotype 2a of hepatitis C virus reveal two conformations and suggest mechanisms of inhibition by non-nucleoside inhibitors.
ChainA
Resolution2.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
3.4.21.98: hepacivirin.
3.4.22.-
3.6.1.15: nucleoside-triphosphate phosphatase.
3.6.4.13: RNA helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 JPC A R422 M423 H475 T476 Y477 L497 R498 K501 W528 R422 M423 H475 T476 Y477 L497 R498 K501 W528 MOAD: ic50=4.4uM
PDBbind-CN: -logKd/Ki=5.36,IC50=4.4uM
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003968 RNA-dependent RNA polymerase activity
Biological Process
GO:0039694 viral RNA genome replication

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Molecular Function
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Biological Process
External links
PDB RCSB:1yvz, PDBe:1yvz, PDBj:1yvz
PDBsum1yvz
PubMed15746101
UniProtP26660|POLG_HCVJ6 Genome polyprotein

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