Structure of PDB 1yuc Chain A

Receptor sequence
>1yucA (length=240) Species: 9606 (Homo sapiens) [Search protein sequence]
ASIPHLILELLKCEPDEPQVQAKIMAYLQQEQANRSKHEKLSTFGLMCKM
ADQTLFSIVEWARSSIFFRELKVDDQMKLLQNCWSELLILDHIYRQVVHG
KEGSIFLVTGQQVDYSIIASQAGATLNNLMSHAQELVAKLRSLQFDQREF
VCLKFLVLFSLDVKNLENFQLVEGVQEQVNAALLDYTMCNYPQQTEKFGQ
LLLRLPEIRAISMQAEEYLYYKHLNGDVPYNNLLIEMLHA
3D structure
PDB1yuc Modulation of human nuclear receptor LRH-1 activity by phospholipids and SHP
ChainA
Resolution1.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A F354 R361 M375 Q379 N530 L531 E534 M535 F56 R63 M77 Q81 N232 L233 E236 M237
BS02 EPH A F342 M345 C346 L386 H390 L405 I416 G421 L424 M428 A513 Y516 K520 F44 M47 C48 L88 H92 L107 I118 G123 L126 M130 A215 Y218 K222
BS03 EPH A H336 E337 H38 E39
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity

View graph for
Molecular Function
External links
PDB RCSB:1yuc, PDBe:1yuc, PDBj:1yuc
PDBsum1yuc
PubMed15723037
UniProtO00482|NR5A2_HUMAN Nuclear receptor subfamily 5 group A member 2 (Gene Name=NR5A2)

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