Structure of PDB 1yu9 Chain A

Receptor sequence
>1yu9A (length=175) Species: 9606 (Homo sapiens) [Search protein sequence]
GPLGSETYDFLFKFLVIGNAGTGKSCLLHQFIEKKFKDDSNHTIGVEFGS
KIINVGGKYVKLQIWDTAGQERFRSVTRSYYRGAAGALLVYDITSRETYN
ALTNWLTDARMLASQNIVIILCGNKKDLDADREVTFLEASRFAQENELMF
LETSALTGEDVEEAFVQCARKILNK
3D structure
PDB1yu9 Structural basis of family-wide Rab GTPase recognition by rabenosyn-5.
ChainA
Resolution2.07 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) Q67
Catalytic site (residue number reindexed from 1) Q70
Enzyme Commision number 3.6.5.2: small monomeric GTPase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG A S22 T40 S25 T43
BS02 GNP A A17 G18 G20 K21 S22 C23 S37 H39 T40 G66 N121 K122 D124 L125 S151 A152 L153 A20 G21 G23 K24 S25 C26 S40 H42 T43 G69 N124 K125 D127 L128 S154 A155 L156
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005525 GTP binding
Biological Process
GO:0032482 Rab protein signal transduction

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Molecular Function
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Biological Process
External links
PDB RCSB:1yu9, PDBe:1yu9, PDBj:1yu9
PDBsum1yu9
PubMed16034420
UniProtP20338|RAB4A_HUMAN Ras-related protein Rab-4A (Gene Name=RAB4A)

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