Structure of PDB 1ytw Chain A

Receptor sequence
>1ytwA (length=283) Species: 630 (Yersinia enterocolitica) [Search protein sequence]
VSPYGPEARAELSSRLTTLRNTLAPATNDPRYLQACGGEKLNRFRDIQCR
RQTAVRADLNANYIQVGNTRTIACQYPLQSQLESHFRMLAENRTPVLAVL
ASSSEIANQRFGMPDYFRQSGTYGSITVESKMTQQVGLGDGIMADMYTLT
IREAGQKTISVPVVHVGNWPDQTAVSSEVTKALASLVDQTAETKRNMYES
KGSSAVADDSKLRPVIHCRAGVGRTAQLIGAMCMNDSRNSQLSVEDMVSQ
MRVQRNGIMVQKDEQLDVLIKLAEGQGRPLLNS
3D structure
PDB1ytw The X-ray crystal structures of Yersinia tyrosine phosphatase with bound tungstate and nitrate. Mechanistic implications.
ChainA
Resolution2.4 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) E290 W354 D356 H402 C403 R409 T410
Catalytic site (residue number reindexed from 1) E105 W169 D171 H217 C218 R224 T225
Enzyme Commision number 3.1.3.48: protein-tyrosine-phosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 WO4 A D356 C403 R404 A405 V407 G408 R409 Q446 D171 C218 R219 A220 V222 G223 R224 Q261
Gene Ontology
Molecular Function
GO:0004725 protein tyrosine phosphatase activity
Biological Process
GO:0006470 protein dephosphorylation
GO:0016311 dephosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:1ytw, PDBe:1ytw, PDBj:1ytw
PDBsum1ytw
PubMed8702535
UniProtP15273|YOPH_YEREN Tyrosine-protein phosphatase YopH (Gene Name=yopH)

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