Structure of PDB 1yts Chain A

Receptor sequence
>1ytsA (length=278) Species: 630 (Yersinia enterocolitica) [Search protein sequence]
PEARAELSSRLTTLRNTLAPATNDPRYLQACGGEKLNRFRDIQCRRQTAV
RADLNANYIQVGNTRTIACQYPLQSQLESHFRMLAENRTPVLAVLASSSE
IANQRFGMPDYFRQSGTYGSITVESKMTQQVGLGDGIMADMYTLTIREAG
QKTISVPVVHVGNWPDQTAVSSEVTKALASLVDQTAETKRNMYESKGSSA
VADDSKLRPVIHSRAGVGRTAQLIGAMCMNDSRNSQLSVEDMVSQMRVQR
NGIMVQKDEQLDVLIKLAEGQGRPLLNS
3D structure
PDB1yts A ligand-induced conformational change in the Yersinia protein tyrosine phosphatase.
ChainA
Resolution2.5 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) E290 W354 D356 H402 S403 R409 T410
Catalytic site (residue number reindexed from 1) E100 W164 D166 H212 S213 R219 T220
Enzyme Commision number 3.1.3.48: protein-tyrosine-phosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SO4 A S403 R404 G406 G408 R409 S213 R214 G216 G218 R219
BS02 SO4 A R278 S388 S389 A390 R88 S198 S199 A200
Gene Ontology
Molecular Function
GO:0004725 protein tyrosine phosphatase activity
Biological Process
GO:0006470 protein dephosphorylation
GO:0016311 dephosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:1yts, PDBe:1yts, PDBj:1yts
PDBsum1yts
PubMed8528087
UniProtP15273|YOPH_YEREN Tyrosine-protein phosphatase YopH (Gene Name=yopH)

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