Structure of PDB 1ysg Chain A

Receptor sequence
>1ysgA (length=181) Species: 9606 (Homo sapiens) [Search protein sequence]
MSMAMSQSNRELVVDFLSYKLSQKGYSWSQFSDVEENRTEAPEGTESEAV
KQALREAGDEFELRYRRAFSDLTSQLHITPGTAYQSFEQVVNELFRDGVN
WGRIVAFFSFGGALCVESVDKEMQVLVSRIAAWMATYLNDHLEPWIQENG
GWDTFVELYGNNAAAESRKGQERLEHHHHHH
3D structure
PDB1ysg An inhibitor of Bcl-2 family proteins induces regression of solid tumours
ChainA
ResolutionN/A
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 4FC A F101 Y105 A108 F109 L134 G142 R143 A146 F61 Y65 A68 F69 L94 G102 R103 A106 PDBbind-CN: -logKd/Ki=3.52,Kd=0.30mM
BindingDB: Kd=300000nM,EC50=>31500nM,IC50=>99200nM
BS02 TN1 A A97 E100 F101 V145 Y199 A57 E60 F61 V105 Y159 BindingDB: Kd=4300000nM
Gene Ontology
Biological Process
GO:0042981 regulation of apoptotic process

View graph for
Biological Process
External links
PDB RCSB:1ysg, PDBe:1ysg, PDBj:1ysg
PDBsum1ysg
PubMed15902208
UniProtQ07817|B2CL1_HUMAN Bcl-2-like protein 1 (Gene Name=BCL2L1)

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