Structure of PDB 1yqy Chain A

Receptor sequence
>1yqyA (length=514) Species: 1392 (Bacillus anthracis) [Search protein sequence]
LSRYEKWEKIKQHYQHWSDSLSEEGRGLLKKLQIPIEPKKDDIIHSLSQE
EKELLKRIQIDSSDFLSTEEKEFLKKLQIDIRDSLSEEEKELLNRIQVDS
SNPLSEKEKEFLKKLKLDIQPYDINQRLQDTGGLIDSPSINLDVRKQYKR
DIQNIDALLHQSIGSTLYNKIYLYENMNINNLTATLGADLVDSTDNTKIN
RGIFNEFKKNFKYSISSNYMIVDINERPALDNERLKWRIQLSPDTRAGYL
ENGKLILQRNIGLEIKDVQIIKQSEKEYIRIDAKVVPKSKIDTKIQEAQL
NINQEWNKALGLPKYTKLITFNVHNRYASNIVESAYLILNEWKNNIQSDL
IKKVTNYLVDGNGRFVFTDITLPNIAEQYTHQDEIYEQVHSKGLYVPESR
SILLHGPSKGVELRNDSEGFIHEFGHAVDDYAGYLLDKNQSDLVTNSKKF
IDIFKEEGSNLTSYGRTNEAEFFAEAFRLMHSTDHAERLKVQKNAPKTFQ
FINDQIKFIINSLV
3D structure
PDB1yqy Anthrax lethal factor inhibition.
ChainA
Resolution2.3 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H686 E687 H690 Y728 E735
Catalytic site (residue number reindexed from 1) H422 E423 H426 Y464 E471
Enzyme Commision number 3.4.24.83: anthrax lethal factor endopeptidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A H686 H690 E735 H422 H426 E471
BS02 915 A D328 S655 K656 G657 L677 H686 E687 H690 Y728 E735 E739 D64 S391 K392 G393 L413 H422 E423 H426 Y464 E471 E475 MOAD: Ki=24nM
PDBbind-CN: -logKd/Ki=7.62,Ki=24nM
BindingDB: Ki=24nM,IC50=54nM
Gene Ontology
Molecular Function
GO:0008237 metallopeptidase activity

View graph for
Molecular Function
External links
PDB RCSB:1yqy, PDBe:1yqy, PDBj:1yqy
PDBsum1yqy
PubMed15911756
UniProtP15917|LEF_BACAN Lethal factor (Gene Name=lef)

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