Structure of PDB 1yq4 Chain A

Receptor sequence

>1yq4A (length=614) Species: 9031 (Gallus gallus) [Search protein sequence]

ISTQYPVVDHEFDAVVVGAGGAGLRAAFGLSEAGFNTACVTKLFPTRSHT
VAAQGGINAALGNMEDDNWRWHFYDTVKGSDWLGDQDAIHYMTEQAPAAV
IELENYGMPFSRTEEGKIYQRAFGGQSLQFGKGGQAHRCCCVADRTGHSL
LHTLYGRSLRYDTSYFVEYFALDLLMENGECRGVIALCIEDGTIHRFRAK
NTVIATGGYGRTYFSCTSAHTSTGDGTAMVTRAGLPCQDLEFVQFHPTGI
YGAGCLITEGCRGEGGILINSQGERFMERYAPVAKDLASRDVVSRSMTIE
IREGRGCGPEKDHVYLQLHHLPPQQLATRLPGISETAMIFAGVDVTKEPI
PVLPTVHYNMGGIPTNYKGQVITHVNGEDKVVPGLYACGEAASASVHGAN
RLGANSLLDLVVFGRACALTIAETCKPGEPVPSIKPNAGEESVANLDKLR
FADGTIRTSEARLNMQKTMQSHAAVFRTGSILQEGCEKLSQIYRDLAHLK
TFDRGIVWNTDLVETLELQNLMLCALQTIYGAEARKESRGAHAREDYKLR
IDEFDYSKPLQGQQKRPFEEHWRKHTLSYVDVKSGKVTLKYRPVIDRTLN
EEDCSSVPPAIRSY

3D structure

PDB

1yq4 3-Nitropropionic Acid Is a Suicide Inhibitor of Mitochondrial Respiration That, upon Oxidation by Complex II, Forms a Covalent Adduct with a Catalytic Base Arginine in the Active Site of the Enzyme

Chain

Resolution

2.33 Å

3D
structure

Catalytic site residues are labeled in the structure
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Enzymatic activity

Catalytic site (original residue number in PDB)	F130 Q251 H253 L263 E266 R269 R297 H364 Y365 R408
Catalytic site (residue number reindexed from 1)	F123 Q244 H246 L256 E259 R262 R290 H357 Y358 R401
Enzyme Commision number	1.3.5.1: succinate dehydrogenase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	FAD	A	G25 A26 G27 A29 T48 K49 L50 S55 H56 T57 A59 A60 Q61 G63 F177 A178 A212 T213 T224 D232 L263 H364 Y365 G396 E397 R408 A411 S413 L414 L417	G18 A19 G20 A22 T41 K42 L43 S48 H49 T50 A52 A53 Q54 G56 F170 A171 A205 T206 T217 D225 L256 H357 Y358 G389 E390 R401 A404 S406 L407 L410
BS02	3NP	A	G62 F130 H253 T265 E266 R297 H364	G55 F123 H246 T258 E259 R290 H357

Gene Ontology

	Molecular Function
GO:0008177	succinate dehydrogenase (quinone) activity
GO:0009055	electron transfer activity
GO:0016491	oxidoreductase activity
GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors
GO:0050660	flavin adenine dinucleotide binding

	Biological Process
GO:0006099	tricarboxylic acid cycle
GO:0006105	succinate metabolic process
GO:0006121	mitochondrial electron transport, succinate to ubiquinone
GO:0022900	electron transport chain
GO:0022904	respiratory electron transport chain

	Cellular Component
GO:0005739	mitochondrion
GO:0005743	mitochondrial inner membrane
GO:0045273	respiratory chain complex II (succinate dehydrogenase)

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Molecular Function

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Cellular Component

External links

PDB	RCSB:1yq4, PDBe:1yq4, PDBj:1yq4
PDBsum	1yq4
PubMed	16371358
UniProt	Q9YHT1\|SDHA_CHICK Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial (Gene Name=SDHA)

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