Structure of PDB 1yok Chain A

Receptor sequence
>1yokA (length=236) Species: 9606 (Homo sapiens) [Search protein sequence]
SIPHLILELLKCEPDEPQVQAKIMAYLQQEQANRSKLSTFGLMCKMADQT
LFSIVEWARSSIFFRELKVDDQMKLLQNCWSELLILDHIYRQVVHGKEGS
IFLVTGQQVDYSIIASQAGATLNNLMSHAQELVAKLRSLQFDQREFVCLK
FLVLFSLDVKNLENFQLVEGVQEQVNAALLDYTMCNYPQQTEKFGQLLLR
LPEIRAISMQAEEYLYYKHLNGDVPYNNLLIEMLHA
3D structure
PDB1yok Structural analyses reveal phosphatidyl inositols as ligands for the NR5 orphan receptors SF-1 and LRH-1.
ChainA
Resolution2.5 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A E358 R361 Q374 M375 Q379 L531 E534 M535 E56 R59 Q72 M73 Q77 L229 E232 M233
BS02 P6L A T341 F342 M345 H390 I416 Q419 G421 T423 L424 L427 A513 Y516 Y519 K520 T39 F40 M43 H88 I114 Q117 G119 T121 L122 L125 A211 Y214 Y217 K218
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity

View graph for
Molecular Function
External links
PDB RCSB:1yok, PDBe:1yok, PDBj:1yok
PDBsum1yok
PubMed15707893
UniProtO00482|NR5A2_HUMAN Nuclear receptor subfamily 5 group A member 2 (Gene Name=NR5A2)

[Back to BioLiP]