Structure of PDB 1yim Chain A

Receptor sequence
>1yimA (length=245) Species: 9606 (Homo sapiens) [Search protein sequence]
ALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVH
MINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAP
NLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNS
GVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQ
LLLILSHIRHMSNKGMEHLYSMKCKNVVPLYDLLLEMLDAHRLHA
3D structure
PDB1yim Estrogen receptor ligands. Part 10: Chromanes: old scaffolds for new SERAMs.
ChainA
Resolution1.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CM4 A L346 T347 A350 D351 E353 W383 L387 F404 M421 G521 H524 L525 K531 L40 T41 A44 D45 E47 W77 L81 F98 M115 G215 H218 L219 K225 MOAD: ic50=1.5nM
BindingDB: IC50=1.5nM
External links
PDB RCSB:1yim, PDBe:1yim, PDBj:1yim
PDBsum1yim
PubMed15745820
UniProtP03372|ESR1_HUMAN Estrogen receptor (Gene Name=ESR1)

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