Structure of PDB 1ygu Chain A

Receptor sequence

>1yguA (length=571) Species: 9606 (Homo sapiens)

EKQLMNVEPIHADILLETYKRKIADEGRPFLAEFQSIPRVFSKFPIKEAR
KPFNQNKNRYVDILPYDYNRVELSEINGDAGSNYINASYIDGFKEPRKYI
AAQGPRDETVDDFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWPSMEEGT
RAFGDVVVKINQHKRCPDYIIQKLNIVNKKEKATGREVTHIQFTSWPDHG
VPEDPHLLLKLRRRVNAFSNFFSGPIVVHSSAGVGRTGTYIGIDAMLEGL
EAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQALVEYNQFGETEVNLS
ELHPYLHNMKKRDPPSEPSPLEAEFQRLPSYRSWRTQHIGNQEENKSKNR
NSNVIPYDYNRVPLKSKYINASFIMSYWKPEVMIAAQGPLKETIGDFWQM
IFQRKVKVIVMLTELKHGDQEICAQYWGEGKQTYGDIEVDLKDTDKSSTY
TLRVFELRHSKRKDSRTVYQYQYTNWSVEQLPAEPKELISMIQVVKQKLP
QKNTPLLIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKARL
GMVSTFEQYQFLYDVIASTYP

3D structure

• PDB: 1ygu Structural basis for the function and regulation of the receptor protein tyrosine phosphatase CD45.
• Chain: A
• Resolution: 2.9 Å

Enzymatic activity

• Catalytic site (original residue number in PDB): D796 S828 R834 T835 Q872
• Catalytic site (residue number reindexed from 1): D198 S230 R236 T237 Q274
• Enzyme Commision number: 3.1.3.48: protein-tyrosine-phosphatase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	A	R657 Y658 D660 H797 S828 S829 A830 V832 G833 R834 Q872	R59 Y60 D62 H199 S230 S231 A232 V234 G235 R236 Q274

Gene Ontology

Molecular Function

• GO:0004725 protein tyrosine phosphatase activity

Biological Process

• GO:0006470 protein dephosphorylation
• GO:0016311 dephosphorylation

External links

• PDB: RCSB:1ygu, PDBe:1ygu, PDBj:1ygu
• PDBsum: 1ygu
• PubMed: 15684325
• UniProt: P08575|PTPRC_HUMAN Receptor-type tyrosine-protein phosphatase C (Gene Name=PTPRC)