Structure of PDB 1ygp Chain A

Receptor sequence
>1ygpA (length=858) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence]
TRRLTGFLPQEIKSIDTMIPLLSRALWNKHQVKKFNKAEDFQDRFIDHVE
TTLARSLYNCDDMVAYEAASMSIRDNLVIDWNKTQQKFTTRDPKRVYYLS
LEFLMGRALDNALINMKIPREMIKGALDELGFKLEDVLDQEPDAGLGNGG
LGRLAACFVDSMATEGIPAWGYGLRYEYGIFAQKIIDGYQVETPDYWLNS
GNPWEIERNEVQIPVTFYGYVDRPTTLSASQWIGGERVLAVAYDFPVPGF
KTSNVNNLRLWQARPTTEFDLNKFNNGDYKNSVAQQQRAESITAVLYPND
NFAQGKELRLKQQYFWCAASLHDILRRFKKSKRPWTEFPDQVAIQLNDTH
PTLAIVELQRVLVDLEKLDWHEAWDIVTKTFAYTNHTVMQEALEKWPRRL
FGHLLPRHLEIIYDINWFFLEDVAKKFPKDVDLLSRISIIEENSPERQIR
MAFLAIVGSHKVNGVVELHSELIKTTIFKDFIKFYGPSKFVNVTNGITPR
RWLKQANPSLAKLISETLNDPTEEYLLDMAKLTQLEKYVEDKEFLKKWNQ
VKLNNKIRLVDLIKKENDGVDIINREYLDDTLFDMQVKRIHEYKRQQLNV
FGIIYRYLAMKNMLKNGASIEEVARKYPRKVSIFGGKSAPGYYMAKLIIK
LINCVADIVNNDESIEHLLKVVFVADYNVSKAEIIIPASDLSEHISTAGT
EASGTSNMKFVMNGGLIIGTVDGANVEITREIGEDNVFLFGNLSENVEEL
RYNHQYHPQDLPSSLDSVLSYIEQFSPENPNEFKPLVDSIKYHGDYYLVS
DDFESYLATHELVDQEFHNQRSEWLKKSVLSLANVGFFSSDRCIEEYSDT
IWNVEPVT
3D structure
PDB1ygp A protein phosphorylation switch at the conserved allosteric site in GP.
ChainA
Resolution2.8 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H377 K568 R569 K574 T676 K680
Catalytic site (residue number reindexed from 1) H386 K588 R589 K594 T705 K709
Enzyme Commision number 2.4.1.1: glycogen phosphorylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 PO4 A T10N R309 R310 T5 R326 R327
BS02 PO4 A G135 R569 G150 R589
BS03 PLP A W491 N649 V650 S677 K680 W502 N678 V679 S706 K709
Gene Ontology
Molecular Function
GO:0004645 1,4-alpha-oligoglucan phosphorylase activity
GO:0005515 protein binding
GO:0008184 glycogen phosphorylase activity
GO:0016757 glycosyltransferase activity
GO:0030170 pyridoxal phosphate binding
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0005977 glycogen metabolic process
GO:0005980 glycogen catabolic process
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1ygp, PDBe:1ygp, PDBj:1ygp
PDBsum1ygp
PubMed8703213
UniProtP06738|PHSG_YEAST Glycogen phosphorylase (Gene Name=GPH1)

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