Structure of PDB 1yf8 Chain A

Receptor sequence
>1yf8A (length=240) Species: 3972 (Viscum album) [Search protein sequence]
YERLDLDVTSQTTGEEYFRFITLLRDYVSSGSFSNEIPLLRQSGGGVEAA
RFVLVELTNEGGDSITAAIDVTNLYVVAYQAGSQSYFLSGPGTHLFTGTT
RSSLPFNGSYPDLEQYAGHRKQIPLGIDQLIQSVTALRFPGNTRTQARSI
LILIQMISEAARFNPILWRARQYINSGASFLPDVYMLELETSWGQQSTQV
QQSTEGVFNNPIRLAIPGNFVTLTNVRDVIASLAIMLFVC
3D structure
PDB1yf8 Crystal structure of himalayan mistletoe ribosome-inactivating protein reveals the presence of a natural inhibitor and a new functionally active sugar-binding site.
ChainA
Resolution2.8 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) V76 E159 R162
Catalytic site (residue number reindexed from 1) V76 E159 R162
Enzyme Commision number 3.2.2.22: rRNA N-glycosylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 P6C A Y75 S109 Y110 R162 W193 Y75 S109 Y110 R162 W193
Gene Ontology
Molecular Function
GO:0030598 rRNA N-glycosylase activity
Biological Process
GO:0017148 negative regulation of translation

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Molecular Function
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Biological Process
External links
PDB RCSB:1yf8, PDBe:1yf8, PDBj:1yf8
PDBsum1yf8
PubMed15774467
UniProtQ6ITZ3|ML4_VISAL Beta-galactoside-specific lectin 4

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