Structure of PDB 1ycr Chain A

Receptor sequence
>1ycrA (length=85) Species: 9606 (Homo sapiens) [Search protein sequence]
ETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQYIMTKRLYDEKQQHI
VYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVV
3D structure
PDB1ycr Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain.
ChainA
Resolution2.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A E25 T26 M50 K51 L54 G58 I61 M62 Q72 H73 V93 K94 H96 Y100 E1 T2 M26 K27 L30 G34 I37 M38 Q48 H49 V69 K70 H72 Y76
Gene Ontology
Biological Process
GO:0043066 negative regulation of apoptotic process
GO:0051726 regulation of cell cycle
Cellular Component
GO:0005634 nucleus

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Biological Process
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Cellular Component
External links
PDB RCSB:1ycr, PDBe:1ycr, PDBj:1ycr
PDBsum1ycr
PubMed8875929
UniProtQ00987|MDM2_HUMAN E3 ubiquitin-protein ligase Mdm2 (Gene Name=MDM2)

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