Structure of PDB 1yc4 Chain A

Receptor sequence
>1yc4A (length=210) Species: 9606 (Homo sapiens) [Search protein sequence]
EEVETFAFQAEIAQLMSLIINTFYSNKEIFLRELISNSSDALDKIRYETL
TDPSKLDSGKELHINLIPNKQDRTLTIVDTGIGMTKADLINNLGTIAKSG
TKAFMEALQAGADISMIGQFGVGFYSAYLVAEKVTVITKHNDDEQYAWES
SAGGSFTVRTDTGEPMGRGTKVILHLKEDQTEYLEERRIKEIVKKHSQFI
GYPITLFVEK
3D structure
PDB1yc4 Crystal structures of human HSP90alpha-complexed with dihydroxyphenylpyrazoles.
ChainA
Resolution1.81 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.4.10: non-chaperonin molecular chaperone ATPase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 43P A N51 A55 K58 D93 I96 G97 M98 F138 T184 N37 A41 K44 D79 I82 G83 M84 F124 T170 MOAD: Kd=0.28uM
PDBbind-CN: -logKd/Ki=6.55,Kd=280nM
BindingDB: Kd=280nM
Gene Ontology
Molecular Function
GO:0005524 ATP binding
GO:0016887 ATP hydrolysis activity
GO:0051082 unfolded protein binding
GO:0140662 ATP-dependent protein folding chaperone
Biological Process
GO:0006457 protein folding

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Molecular Function
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Biological Process
External links
PDB RCSB:1yc4, PDBe:1yc4, PDBj:1yc4
PDBsum1yc4
PubMed15713410
UniProtP07900|HS90A_HUMAN Heat shock protein HSP 90-alpha (Gene Name=HSP90AA1)

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